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制御性B細胞と自己免疫性疾患
http://hdl.handle.net/2297/29446
http://hdl.handle.net/2297/29446272e9612-386f-4ce6-a1ac-1ecd4a2a7682
名前 / ファイル | ライセンス | アクション |
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ME-PR-MATSUSHITA-T-234.pdf (1.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-03 | |||||
タイトル | ||||||
タイトル | 制御性B細胞と自己免疫性疾患 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Regulatory B cell and autoimmune disease | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Matsushita, Takashi
× Matsushita, Takashi |
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書誌情報 |
日本臨床免疫学会会誌 = Japanese journal of clinical immunology 巻 33, 号 5, p. 234-241, 発行日 2010-01-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0911-4300 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00357971 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2177/jsci.33.234 | |||||
出版者 | ||||||
出版者 | The Japan Society for Clinical Immunology = 日本臨床免疫学会 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Regulatory B cells that produce IL-10 are now recognized as an important component of the immune system. Hallmark papers from a number of distinguished laboratories have identified phenotypically diverse B cell subsets with regulatory functions during distinct autoimmune diseases, including IL-10-producing B cells, CD5+ B-1a cells, CD1d+ marginal zone B cells, and transitional 2-marginal zone precursor B cells. Most recently, a numerically rare and phenotypically unique CD1dhiCD5 +CD19hi subset of regulatory B cells has been identified in the spleens of both normal and autoimmune mice. Remarkably, regulatory B cells are potent negative regulators of inflammation and autoimmunity in mouse models of disease in vivo. Herein, our current understanding of regulatory B cell function is reviewed in the context of previous studies that have identified and characterized regulatory B cells. © 2010 The Japan Society for Clinical Immunology. 近年,免疫応答におけるIL-10を産生する制御性B細胞の重要性が明らかにされてきた.しかしながら,制御性B細胞の分画の報告としてはB1a細胞(CD5+),Marginal zone B細胞(CD1dhiCD21hi),T2-marginal zone precursor B細胞(CD1dhiCD21hiCD23+IgM+)など統一した見解がなかったが,CD1dhiCD5+CD19hiの表現形であることが明らかとなった.特に,制御性B細胞の研究は自己免疫性疾患モデルマウスを使用した研究で,多くのことが解明されてきた.今回,自己免疫性疾患における制御性B細胞の研究でこれまで解っている知見をまとめ,その機能,治療への応用の可能性につき概説する. | |||||
権利 | ||||||
権利情報 | Copyright (c) 2010 日本臨床免疫学会 / The Japan Society for Clinical Immunology | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://japanlinkcenter.org/JST.JSTAGE/jsci/33.234 |