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EBV関連リンパ増殖性疾患発症とKIRの関連
https://doi.org/10.24517/00057817
https://doi.org/10.24517/0005781731ffa668-5724-423e-abc7-bf9d8163119c
名前 / ファイル | ライセンス | アクション |
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ME-PR-IWAKI-N-kaken 2021-5p.pdf (248.5 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2022-02-17 | |||||
タイトル | ||||||
タイトル | EBV関連リンパ増殖性疾患発症とKIRの関連 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Association of KIR genotype profile on the development of EBV-related iatrogenic immunodeficiency-associated lymphoproliferative disorders | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00057817 | |||||
ID登録タイプ | JaLC | |||||
著者別表示 |
Iwaki, Noriko
× Iwaki, Noriko |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域医学系 | |||||
書誌情報 |
令和2(2020)年度 科学研究費補助金 若手研究 研究成果報告書 en : 2020 Fiscal Year Final Research Report 巻 2019-04-01 - 2021-03-31, p. 5p., 発行日 2021-05-11 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | EBV-LPD(EB virus-associated lymphoproliferative disorder)を発症した患者の全血におけるEBV-DNA copy数を定量的PCRで評価すると共にEBV-LPDを発症した患者と、EBVに関連しない悪性リンパ腫患者、健常人の3群間でKIR 遺伝子プロフィルを比較し、EBV-LPDとKIR遺伝子プロフィルの関係を検討した。結果EBV-LPDを発症した患者では、活性型KIRであるKIR2DS1、KIR2DS5、抑制型KIRである2DL5の保有率が有意に低値であった。患者のKIR 遺伝子プロフィルがEBV-LPDの発症に影響する可能性が示唆された。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | To identify the association between KIR gene polymorphisms and susceptibility to EBV-LPD (EB virus-associated lymphoproliferative disorder), we determined EBV copy numbers in the whole blood of patients suspected of having EBV-LPD using quantitative real-time PCR, and determined the KIR gene profile of these patients as well as those who develop non-EBV associated lymphoma and healthy individuals using PCR with specific primers. In patients with EBV-LPD, the frequencies of KIR2DS1, 2DS5 and 2DL5 were significantly lower than those in healthy individuals and non-EBV associated lymphoma. The result suggests that the KIR gene repertoire may be associated with susceptibility to EBV-LPD. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:19K17825, 研究期間(年度):2019-04-01 - 2021-03-31 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:「EBV関連リンパ増殖性疾患発症とKIRの関連」研究成果報告書 課題番号19K17825 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19K17825/19K17825seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=10825706 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=10825706 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K17825/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K17825/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19K17825/19K17825seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19K17825/19K17825seika/ |