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GABPα regulates Oct-3/4 expression in mouse embryonic stem cells
http://hdl.handle.net/2297/3552
http://hdl.handle.net/2297/3552d7ba56d4-0c05-4b3c-8560-b512f7d13b36
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-YOKOTA-T-686.fdf (5.1 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | GABPα regulates Oct-3/4 expression in mouse embryonic stem cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Kinoshita, Keita
× Kinoshita, Keita× Ura, Hiroki× Akagi, Tadayuki× Usuda, Masayuki× Koide, Hiroshi× Yokota, Takashi |
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| 提供者所属 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 金沢大学大学院医学系研究科機能再生学 | |||||
| 書誌情報 |
Biochemical and Biophysical Research Communications 巻 353, 号 3, p. 686-691, 発行日 2007-02-16 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0006-291X | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.bbrc.2006.12.071 | |||||
| 出版者 | ||||||
| 出版者 | Academic Press | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Embryonic stem (ES) cells are pluripotent cells derived from the inner cell mass of blastocysts, and transcription factors Oct-3/4, Nanog, Sox2, and STAT3, are essential for their self-renewal. In this study, we searched for molecules downstream of STAT3 in ES cells. Using DNA chip analysis, we obtained GA-repeat binding protein (GABP) α. Expression of GABPα was restricted to undifferentiated ES cells and controlled by STAT3. We found that the expression level of Oct-3/4 is reduced by knockdown of GABPα. On the other hand, GABPα-overexpressing ES cells maintained the expression level of Oct-3/4 even in the absence of LIF. Moreover, the induction of Oct-3/4 repressors Cdx-2, Coup-tf1, and GCNF was stimulated by GABPα knockdown. These data suggest that GABPα upregulates the expression of Oct-3/4 via downregulation of Oct-3/4 repressors. © 2006 Elsevier Inc. All rights reserved. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
