WEKO3
インデックスリンク
アイテム
Cytosolic Ca2+ alteration mediates both ryanodine receptor and IP3 receptor in TE671/RD cells
http://hdl.handle.net/2297/14432
http://hdl.handle.net/2297/1443250f5ab4f-4a5d-4b05-906a-cba9840dc788
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-HASHII-M-255.pdf (155.3 kB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | Cytosolic Ca2+ alteration mediates both ryanodine receptor and IP3 receptor in TE671/RD cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Edahiro, Shigeki
× Edahiro, Shigeki× Yoshikawa, Hiroaki× Iwasa, Kazuo× Hashii, Minako× Yamada, Masahito |
|||||
| 提供者所属 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 金沢大学医薬保健研究域医学系 | |||||
| 書誌情報 |
Biomedical Research 巻 25, 号 6, p. 255-261, 発行日 2004-12-01 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0388-6107 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00110128 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.2220/biomedres.25.255 | |||||
| 出版者 | ||||||
| 出版者 | Biomedical Research | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | TE671 is a cell line obtained from the rhabdomyosarcoma cells. In the present study, we examined [Ca2+]i alteration induced by acetylcholine (ACh) in TE671/RD cells with the special attention to ryanodine receptor (RyR) and inositol 1,4,5-triphosphate receptor (IP3R). The change of [Ca2+]i was mediated by muscarinic type 3 (m3) AChR. Both phosphatidylinositol-specific phospholipase C blocker (U73122) and IP3R blocker (2-APB) inhibited ACh-induced [Ca2+]i elevation, suggesting that IP3 pathway is involved in [Ca2+]i alteration. Ryanodine and FK506 increased ACh-induced [Ca2+]i elevation, which was decreased by RyR blocker (ruthenium red). These results suggest that RyR and FK506 binding protein 12 kDa (FKBP12) complex was involved in [Ca2+]i change, and that TE671/RD cell line has a hybrid characteristic of smooth and skeletal muscles. Copyright © 2005 Biomedical Research Press. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 関連URI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | http://dx.doi.org/10.2220/biomedres.25.255 | |||||
