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Generation of a transgenic mouse line for conditional expression of human IL-6
http://hdl.handle.net/2297/46746
http://hdl.handle.net/2297/46746e86e362e-6577-41da-bf8f-3cc3fff8a310
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-NAKAMURA-H-455.pdf (1.8 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | Generation of a transgenic mouse line for conditional expression of human IL-6 | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Mori, Taiki
× Mori, Taiki× Murasawa, Yusuke× Ikai, Rina× Hayakawa, Tomoko× Nakamura, Hiroyuki× Ogiso, Noboru× Niida, Shumpei× Watanabe, Ken |
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| 書誌情報 |
Experimental Animals 巻 65, 号 4, p. 455-463, 発行日 2016-01-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1341-1357 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11032321 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1538/expanim.16-0043 | |||||
| 出版者 | ||||||
| 出版者 | 日本実験動物学会 = Japanese Association for Laboratory Animal Science | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | IL-6 is a cytokine that is involved in various physiological and pathological conditions, and approaches using gain-of-function transgenic animals have contributed in elucidating IL-6 function. However, studies of the multiple functions of IL-6 in vivo are very time consuming because they require the generation of transgenic mice that harbor the gene encoding IL-6 under the control of specific promoters to mimic different pathologies. Here, we report the establishment of a conditional human IL-6 transgenic mouse, LGL-IL6, which conditionally expresses human IL-6 by taking advantage of the well-characterized Cre recombinase drivers. | |||||
| 権利 | ||||||
| 権利情報 | Copyright © 2016 Japanese Association for Laboratory Animal Science 日本実験動物学会 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.jalas.jp/ | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.jstage.jst.go.jp/browse/expanim | |||||
