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Concanavalin A-mediated T cell proliferation is regulated by herpes virus entry mediator costimulatory molecule
http://hdl.handle.net/2297/36268
http://hdl.handle.net/2297/36268e2bdfe5c-2a8b-4069-8ddf-2916ca2d0e2a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
PH-PR-INOBE-M-313author.pdf (817.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-10-04 | |||||
| タイトル | ||||||
| タイトル | Concanavalin A-mediated T cell proliferation is regulated by herpes virus entry mediator costimulatory molecule | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Ando, Yoshiaki
× Ando, Yoshiaki× Yasuoka, Chika× Mishima, Takuya× Ikematsu, Takuya× Uede, Toshimitsu× Matsunaga, Tsukasa× Inobe, Manabu |
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| 書誌情報 |
In Vitro Cellular and Developmental Biology - Animal 巻 50, 号 4, p. 313-320, 発行日 2014-04-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1071-2690 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11003480 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s11626-013-9705-2 | |||||
| 出版者 | ||||||
| 出版者 | Society for In-Vitro Biology / Springer Verlag (Germany) | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | T cell activation is regulated by two distinct signals, signals one and two. Concanavalin A (ConA) is an antigen-independent mitogen and functions as signal one inducer, leading T cells to polyclonal proliferation. CD28 is known to be one of major costimulatory receptors and to provide signal two in the ConA-induced T cell proliferation. Here, we have studied the implication of other costimulatory pathways in the ConA-mediated T cell proliferation by using soluble recombinant proteins consisting of an extracellular domain of costimulatory receptors and Fc portion of human IgG. We found that T cell proliferation induced by ConA, but not PMA plus ionomycin or anti-CD3 mAb, is significantly inhibited by herpes virus entry mediator (HVEM)-Ig, even in the presence of CD28 signaling. Moreover, the high concentration of HVEM-Ig molecules almost completely suppressed ConA-mediated T cell proliferation. These results suggest that HVEM might play more important roles than CD28 in ConA-mediated T cell proliferation. © 2013 The Society for In Vitro Biology. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
