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肝細胞増殖因子の発現は骨格筋再生領域の拡大と同期する
http://hdl.handle.net/2297/44370
http://hdl.handle.net/2297/443700dca0eb9-b611-4f09-8316-58bed91d6692
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA11599711-39-2-85-94.pdf (1.3 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-10-04 | |||||
| タイトル | ||||||
| タイトル | 肝細胞増殖因子の発現は骨格筋再生領域の拡大と同期する | |||||
| タイトル | ||||||
| タイトル | Expression of hepatocyte growth factor is synchronized with expansion of myogenesis in regenerating skeletal muscle | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | skeletal muscle regeneration | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | hepatocyte growth factor | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | satellite cell | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | c-Met | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
田中, 正二
× 田中, 正二× 河原, 榮× 中川, 敬夫 |
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| 書誌情報 |
金沢大学つるま保健学会誌 = Journal of the Tsuruma Health Science Society, Kanazawa University 巻 39, 号 2, p. 85-94, 発行日 2016-01-27 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1346-8502 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11599711 | |||||
| 出版者 | ||||||
| 出版者 | 金沢大学つるま保健学会 = Tsuruma Health Science Society, Kanazawa University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The role of hepatocyte growth factor （HGF）-induced activation （phosphorylation） of its receptor, c-Met, and subsequent downstream signaling during muscle regeneration has not yet been adequately determined. We examined HGF and phospho-c-Met expression and localization during the expansion phase and time course of satellite cell activation, which is critical for muscle regeneration after injury. HGF, c-Met, myogenic differentiation 1 （MyoD）, and myogenin mRNA levels were significantly increased during muscle regeneration after injury. Phospho-c-Met was localized on the surface of regenerating muscle cells. HGF was colocalized in the same cells as phospho-c-Met, MyoD, or myogenin. The muscle area occupied by HGF-, phospho-c-Met-, MyoD-, or myogenin-positive cells expanded along with expansion of regenerating muscle. Thus, c-Met is expressed in regenerating muscle cells immediately after injury, and its kinase activity is likely activated by HGF expressed by the same cells, suggesting that HGF and c-Met contribute to myogenesis in vivo. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
