| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-10-05 |
| タイトル |
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タイトル |
14-Cmethionine uptake as a potential marker of inflammatory processes after myocardial ischemia and reperfusion |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| ID登録 |
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ID登録 |
10.24517/00026791 |
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ID登録タイプ |
JaLC |
| 著者 |
Taki, Junichi
Wakabayashi, Hiroshi
Inaki, Anri
Imanaka-Yoshida, Kyoko
Hiroe, Michiaki
Ogawa, Kazuma
Morooka, Miyako
Kubota, Kazuo
Shiba, Kazuhiro
Yoshida, Toshimichi
Kinuya, Seigo
|
| 著者別表示 |
瀧, 淳一
若林, 大志
稲木, 杏吏
小川, 数馬
柴, 和弘
絹谷, 清剛
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| 提供者所属 |
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内容記述タイプ |
Other |
|
内容記述 |
金沢大学新学術創成研究機構 / 金沢大学附属病院 |
| 書誌情報 |
Journal of Nuclear Medicine
巻 54,
号 3,
p. 431-436,
発行日 2013-03-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0161-5505 |
| NCID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00703684 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.2967/jnumed.112.112060 |
| 出版者 |
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出版者 |
Society of Nuclear Medicine |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
A relationship between L-[methyl-11C]methionine (11C-methionine) uptake and angiogenesis has been suggested in gliomas. However, methionine uptake in myocardial ischemia and reperfusion has received little attention. We investigated the serial changes and mechanisms of 14-Cmethionine uptake in a rat model of myocardial ischemia and reperfusion. Methods: The left coronary artery was occluded for 30 min, followed by reperfusion for 1-28 d. At the time of the study, 14-Cmethionine (0.74 MBq) and 201Tl (14.8 MBq) were injected intravenously at 20 and 10 min before sacrifice, respectively. One minute before sacrifice, the left coronary artery was reoccluded, and 99mTc-hexakis-2-methoxyisobutylisonitrile (150-180 MBq) was injected to verify the area at risk. Histologic sections of the heart were immunohistochemically analyzed using anti-CD68, anti-smooth-muscle a-actin (SMA), and antitroponin I and compared with the autoradiography findings. Results: Both 14Cmethionine (uptake ratio, 0.71 ± 0.13) and 201Tl uptake were reduced in the area at risk at 1 d after reperfusion. However, 3 d after reperfusion, an increased 14-Cmethionine uptake (1.79 ± 0.23) was observed corresponding to the area of still-reduced 201Tl uptake, and the 14-Cmethionine uptake gradually declined until 28 d. The increased 14-Cmethionine uptake area at 3 and 7 d corresponded well to the macrophage infiltrations demonstrated by positive CD68 staining. Anti-SMA staining appeared at 7 d, after which CD68 staining was gradually replaced by the SMA staining, suggesting that methionine uptake in the early phase after ischemia and reperfusion might reflect inflammatory activity. Conclusion: 14-Cmethionine accumulated in the infarcted area, and its uptake corresponded closely to macrophage infiltration at 3-7 d after reperfusion. Methionine imaging may be useful for inflammatory imaging early after myocardial infarction. COPYRIGHT © 2013 by the Society of Nuclear Medicine and Molecular Imaging, Inc. |
| 著者版フラグ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
HO-PR-TAKI-J-431.pdf (866.2 kB)
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