{"_buckets": {"deposit": "4defc627-7057-403d-bf67-e97dfc7ed0a0"}, "_deposit": {"created_by": 3, "id": "26892", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "26892"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00026892", "sets": ["1763"]}, "author_link": ["21707", "21711", "21709"], "item_4_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1999-09-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "9", "bibliographicPageEnd": "763", "bibliographicPageStart": "757", "bibliographicVolumeNumber": "20", "bibliographic_titles": [{"bibliographic_title": "胆と膵 = The Biliary tract \u0026 pancreas"}]}]}, "item_4_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "膵癌では胃癌や大腸癌のように生検が行えないことが, その早期診断や鑑別診断を困難にしているが, K－rasコドン12の変異が高率にみられることに注目し, 膵液中K－ras変異の検出が試みられている. しかし, その陽性率は高いものの, 偽陽性がかなりみられ, 癌特異性が問題になっている. このような点を補完し, 膵液中DNA診断の向上を目指して, 私共は, p53癌抑制遺伝子変異の有無をnon－RI－SSCP法にて検討している. 本法によるp53遺伝子変異（エクソン5～8）は膵癌の42.3%（11/26）に認められている. 一方, 粘液産生膵腫瘍（腺腫）4例と慢性膵炎16例の膵液には同変異は検出されず, その癌特異性は非常に高い. また, K－ras変異陰性例にもp53変異陽性例がみられ, K－ras変異と組み合わせることにより, 膵癌の遺伝子診断が向上する.", "subitem_description_type": "Abstract"}]}, "item_4_publisher_17": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "医学図書出版"}]}, "item_4_relation_28": {"attribute_name": "関連URI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.igakutosho.co.jp/", "subitem_relation_type_select": "URI"}}]}, "item_4_rights_23": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright © 医学図書出版 | 許可を得て登録"}]}, "item_4_source_id_11": {"attribute_name": "NCID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00333226", "subitem_source_identifier_type": "NCID"}]}, "item_4_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0388-9408", "subitem_source_identifier_type": "ISSN"}]}, "item_4_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "渡邊, 弘之"}], "nameIdentifiers": [{"nameIdentifier": "21709", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "30242564", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=30242564"}, {"nameIdentifier": "30242564", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000030242564"}]}, {"creatorNames": [{"creatorName": "山口, 泰志"}], "nameIdentifiers": [{"nameIdentifier": "21707", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "20303315", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=20303315"}, {"nameIdentifier": "20303315", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000020303315"}]}, {"creatorNames": [{"creatorName": "澤武, 紀雄"}], "nameIdentifiers": [{"nameIdentifier": "21711", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90019969", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90019969"}, {"nameIdentifier": "90019969", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000090019969"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-10-05"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "CA-PR-WATANABE-H-757.pdf", "filesize": [{"value": "4.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, 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"p53癌抑制遺伝子変異検索の膵癌診断"}, {"subitem_title": "Detection of P53 Suppressor Gene Mutations in the Diagnosis of Pancreatic Cancer", "subitem_title_language": "en"}]}, "item_type_id": "4", "owner": "3", "path": ["1763"], "permalink_uri": "http://hdl.handle.net/2297/40638", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-10-05"}, "publish_date": "2017-10-05", "publish_status": "0", "recid": "26892", "relation": {}, "relation_version_is_last": true, "title": ["p53癌抑制遺伝子変異検索の膵癌診断"], "weko_shared_id": -1}