WEKO3
インデックスリンク
アイテム
{"_buckets": {"deposit": "b04535ad-cd46-4c64-a2cd-e7cdac58d325"}, "_deposit": {"created_by": 3, "id": "27452", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "27452"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00027452", "sets": ["1779"]}, "author_link": ["31151", "47764", "10118"], "item_4_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2001-04-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "396", "bibliographicPageStart": "393", "bibliographicVolumeNumber": "34", "bibliographic_titles": [{"bibliographic_title": "日本消化器外科学会雑誌 = The Japanese journal of gastroenterological surgery"}]}]}, "item_4_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "今回,tumor dormancyを目的とした化学療法として,CPT-11の低用量投与法を試みた.低用量投与としては,25mg/m^2をday1,2,3/wで毎週継続するレジメとした.対象は,転移性胃癌と大腸癌,それぞれ8例,計16例である.その結果,低用量投与では副作用が激減し,grade3以上の骨髄抑制を3例(18.6%)をみるのみであった.また投与期間は著明に延長し,平均7.1月で従来法1.8月の約4倍にも相当した.抗腫瘍効果では,奏効率が50%と従来法の29.4%と大きな差は認められなかったが,time to progression (TTP)では,低用量群では平均5.3月と,従来法群の1.6月と3倍以上の差が認められた.またmedian survival time (MST)もそれぞれ11.5月,4.5月と有意差が認められた.以上本法は,縮小よりもTTPの延長から生存期間の延長をもたらす化学療法,いわゆる\"dormant chemotherapy\"と考えられた. We tried a new regimen with frequent administration of low-dose CPT-11 to reduce side effects without any impairing efficacy, administering 25mg/m^2 of CPT-11 continuously on days 1, 2, and 3 of each week in 8 patients with metastatic colon cancer and 8 with metastatic gastric cancer. Grade-3 marrow depression occurred in only 3 patients. Of our 16 patients, 8 had PR, 7 had NC, and 1 had PD, showing a 50% efficacy. Time to progression (TTP) averaged 5.3 months and median survival time (MST) 11.5 months, significantly superior to rusults for the conventional CPT-11 regimen. These results suggest that the low-dose CPT-11 regimen is promising and potential by reduces side eflects and strengthens the antitumor effect, inducing prolonged TTP and survival.", "subitem_description_type": "Abstract"}]}, "item_4_publisher_17": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "日本消化器外科学会 = Japanese Society of Gastroenterological Surgery"}]}, "item_4_relation_28": {"attribute_name": "関連URI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.jsgs.or.jp/", "subitem_relation_type_select": "URI"}}, {"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://ci.nii.ac.jp/naid/110001341036", "subitem_relation_type_select": "URI"}}]}, "item_4_rights_23": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "日本消化器外科学会 | 本文データは学協会の許諾に基づきCiNiiから複製したものである"}]}, "item_4_source_id_11": {"attribute_name": "NCID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00192066", "subitem_source_identifier_type": "NCID"}]}, "item_4_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0386-9768", "subitem_source_identifier_type": "ISSN"}]}, "item_4_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "高橋, 豊"}], "nameIdentifiers": [{"nameIdentifier": "10118", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "10179541", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=10179541"}, {"nameIdentifier": "10179541", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000010179541"}]}, {"creatorNames": [{"creatorName": "北方, 秀一"}], "nameIdentifiers": [{"nameIdentifier": "47764", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "磨伊, 正義"}], "nameIdentifiers": [{"nameIdentifier": "31151", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80092807", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=80092807"}, {"nameIdentifier": "80092807", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000080092807"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-10-05"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "CA-PR-TAKAHASHI-Y-393.pdf", "filesize": [{"value": "427.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 427700.0, "url": {"label": "CA-PR-TAKAHASHI-Y-393.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/27452/files/CA-PR-TAKAHASHI-Y-393.pdf"}, "version_id": "416b297f-259c-4372-8515-990e670bd420"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "low dose chemotherapy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "tumor dormancy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CPT-11", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Tumor dormancy therapyを目指した化学療法,CPT-11による\"Dormant chemotherapy\"", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Tumor dormancy therapyを目指した化学療法,CPT-11による\"Dormant chemotherapy\""}, {"subitem_title": "Low-Dose CPT-11 for Inducing Tumor Dormancy in Metastatic Colon and Gastric Cancers for", "subitem_title_language": "en"}]}, "item_type_id": "4", "owner": "3", "path": ["1779"], "permalink_uri": "http://hdl.handle.net/2297/32264", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-10-05"}, "publish_date": "2017-10-05", "publish_status": "0", "recid": "27452", "relation": {}, "relation_version_is_last": true, "title": ["Tumor dormancy therapyを目指した化学療法,CPT-11による\"Dormant chemotherapy\""], "weko_shared_id": -1}
Tumor dormancy therapyを目指した化学療法,CPT-11による"Dormant chemotherapy"
http://hdl.handle.net/2297/32264
http://hdl.handle.net/2297/322640ec72988-1b6e-456f-a491-af3e0a76eb3d
名前 / ファイル | ライセンス | アクション |
---|---|---|
CA-PR-TAKAHASHI-Y-393.pdf (427.7 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | Tumor dormancy therapyを目指した化学療法,CPT-11による"Dormant chemotherapy" | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Low-Dose CPT-11 for Inducing Tumor Dormancy in Metastatic Colon and Gastric Cancers for | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
高橋, 豊
× 高橋, 豊× 北方, 秀一× 磨伊, 正義 |
|||||
書誌情報 |
日本消化器外科学会雑誌 = The Japanese journal of gastroenterological surgery 巻 34, 号 4, p. 393-396, 発行日 2001-04-01 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0386-9768 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00192066 | |||||
出版者 | ||||||
出版者 | 日本消化器外科学会 = Japanese Society of Gastroenterological Surgery | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 今回,tumor dormancyを目的とした化学療法として,CPT-11の低用量投与法を試みた.低用量投与としては,25mg/m^2をday1,2,3/wで毎週継続するレジメとした.対象は,転移性胃癌と大腸癌,それぞれ8例,計16例である.その結果,低用量投与では副作用が激減し,grade3以上の骨髄抑制を3例(18.6%)をみるのみであった.また投与期間は著明に延長し,平均7.1月で従来法1.8月の約4倍にも相当した.抗腫瘍効果では,奏効率が50%と従来法の29.4%と大きな差は認められなかったが,time to progression (TTP)では,低用量群では平均5.3月と,従来法群の1.6月と3倍以上の差が認められた.またmedian survival time (MST)もそれぞれ11.5月,4.5月と有意差が認められた.以上本法は,縮小よりもTTPの延長から生存期間の延長をもたらす化学療法,いわゆる"dormant chemotherapy"と考えられた. We tried a new regimen with frequent administration of low-dose CPT-11 to reduce side effects without any impairing efficacy, administering 25mg/m^2 of CPT-11 continuously on days 1, 2, and 3 of each week in 8 patients with metastatic colon cancer and 8 with metastatic gastric cancer. Grade-3 marrow depression occurred in only 3 patients. Of our 16 patients, 8 had PR, 7 had NC, and 1 had PD, showing a 50% efficacy. Time to progression (TTP) averaged 5.3 months and median survival time (MST) 11.5 months, significantly superior to rusults for the conventional CPT-11 regimen. These results suggest that the low-dose CPT-11 regimen is promising and potential by reduces side eflects and strengthens the antitumor effect, inducing prolonged TTP and survival. | |||||
権利 | ||||||
権利情報 | 日本消化器外科学会 | 本文データは学協会の許諾に基づきCiNiiから複製したものである | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.jsgs.or.jp/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://ci.nii.ac.jp/naid/110001341036 |