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Expression of 16 kDa proteolipid of vacuolar-tgpe H+-ATPase in human pancreatic cancer
https://doi.org/10.24517/00049833
https://doi.org/10.24517/000498334d13f05c-55e2-4fd8-badd-4c87a9dc4400
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-ISEKI-S-1511.pdf (1.8 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||
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| 公開日 | 2018-01-25 | |||||||||||||||||||||
| タイトル | ||||||||||||||||||||||
| タイトル | Expression of 16 kDa proteolipid of vacuolar-tgpe H+-ATPase in human pancreatic cancer | |||||||||||||||||||||
| 言語 | ||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||
| ID登録 | ||||||||||||||||||||||
| ID登録 | 10.24517/00049833 | |||||||||||||||||||||
| ID登録タイプ | JaLC | |||||||||||||||||||||
| 著者 |
Ohta, Tetsuo
× Ohta, Tetsuo× Numata, Masayuki× Yagishita, H.× Futagami, Fumio× Tsukioka, Yuhji× Kitagawa, Hirohisa× Kayahara, Masato× Nagakawa, Takukazu× Miyazaki, Itsuo× Yamamoto, Miyuki× Iseki, Shoichi |
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| 著者別表示 |
太田, 哲生
× 太田, 哲生
× 沼田, 雅行
× 北川, 裕久
× 萱原, 正都
× 永川, 宅和
× 宮崎, 逸夫
× 山本, 美由紀
× 井関, 尚一
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| 提供者所属 | ||||||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||||||
| 内容記述 | 金沢大学医薬保健研究域医学系 | |||||||||||||||||||||
| 書誌情報 |
British Journal of Cancer 巻 73, 号 12, p. 1511-1517, 発行日 1996 |
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| ISSN | ||||||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||||||
| 収録物識別子 | 0007-0920 | |||||||||||||||||||||
| NCID | ||||||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||||||
| 収録物識別子 | AA00574355 | |||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||
| 出版者 | Cancer Research UK | |||||||||||||||||||||
| 抄録 | ||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||
| 内容記述 | Recent studies have shown that bafilomycin A1-sensitive vacuolar-type H+-ATPase (V-ATPase) plays important roles in cell growth and differentiation. However, there is no published study that has focused on the expression of V-ATPase in human tumour tissues. This study was designed to examine the mRNA and protein levels for the 16 kilodalton (kDa) proteolipid of V-ATPase in human pancreatic carcinoma tissues. We first investigated the mRNA level for V-ATPase in six cases of invasive pancreatic cancers and two normal pancreases, using reverse transcription-polymerase chain reaction technique. Then, we examined immunohistochemically the level of V-ATPase protein in 49 pancreatic cancers and ten benign cystic neoplasms of the pancreas, using antisera raised against the 16 kDa proteolipid. There was a notable difference in the level of V-ATPase mRNA between normal and pancreatic carcinoma tissues, with no evident difference in the expression of the β-actin gene. Immunohistochemically, 42 out of 46 invasive ductal cancers (92%) displayed a mild to marked immunoreactivity for V-ATPase in the cytoplasm, whereas neither non-invasive ductal cancers nor benign cystic neoplasms expressed detectable immunoreactive proteins. These findings suggest that the overexpression of V-ATPase protein is characteristic of invasive pancreatic tumours. V-ATPase may play some crucial roles in tumour progression. | |||||||||||||||||||||
| 内容記述 | ||||||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||||||
| 内容記述 | Embargo Period 12 months | |||||||||||||||||||||
| 権利 | ||||||||||||||||||||||
| 権利情報 | Copyright © 1996 Stockton Press. | |||||||||||||||||||||
| 著者版フラグ | ||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||
