| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-01-25 |
| タイトル |
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タイトル |
Increased E-selectin in hepatic ischemia-reperfusion injury mediates liver metastasis of pancreatic cancer |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| ID登録 |
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ID登録 |
10.24517/00049840 |
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ID登録タイプ |
JaLC |
| 著者 |
Yoshimoto, Katsuhiro
Tajima, Hidehiro
Ohta, Tetsuo
Okamoto, Koichi
Sakai, Seisho
Kinoshita, Jun
Furukawa, Hiroyuki
Makino, Isamu
Hayashi, Hironori
Nakamura, Keishi
Oyama, Katsunobu
Inokuchi, Masafumi
Nakagawara, Hisatoshi
Itoh, Hiroshi
Fujita, Hideto
Takamura, Hiroyuki
Ninomiya, Itasu
Kitagawa, Hirohisa
Fushida, Sachio
Fujimura, Takashi
Wakayama, Tomohiko
Iseki, Shoichi
Shimizu, Koichi
|
| 著者別表示 |
田島, 秀浩
太田, 哲生
岡本, 浩一
木下, 淳
古川, 裕之
牧野, 勇
林, 泰寛
中村, 慶史
尾山, 勝信
井口, 雅史
中川原, 寿俊
藤田, 秀人
高村, 博之
二宮, 致
藤村, 隆
若山, 友彦
井関, 尚一
清水, 康一
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| 提供者所属 |
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内容記述タイプ |
Other |
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内容記述 |
金沢大学医薬保健研究域医学系 |
| 書誌情報 |
Oncology Reports
巻 28,
号 3,
p. 791-796,
発行日 2012-09
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1021-335X |
| item_4_source_id_11 |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA11016405 |
| DOI |
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|
関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.3892/or.2012.1896 |
| 出版者 |
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出版者 |
Spandidos Publications |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Several recent studies have reported that selectins are produced during ischemia-reperfusion injury, and that selectin ligands play an important role in cell binding to the endothelium and in liver metastasis. Portal clamping during pancreaticoduodenectomy with vessel resection for pancreatic head cancer causes hepatic ischemia-reperfusion injury, which might promote liver metastasis. We investigated the liver colonization of pancreatic cancer cells under hepatic ischemia-reperfusion and examined the involvement of E-selectin and its ligands. A human pancreatic cancer cell line (Capan-1) was injected into the spleen of mice after hepatic ischemia-reperfusion (I/R group). In addition, to investigate the effect of an anti-E-selectin antibody on liver colonization in the IR group, mice received an intraperitoneal injection of the anti-E-selectin antibody following hepatic ischemia-reperfusion and tumor inoculation (IR+Ab group). Four weeks later, mice were sacrificed and the number of tumor nodules on the liver was compared to mice without hepatic ischemia-reperfusion (control group). The incidence of liver metastasis in the I/R group was significantly higher (16 of 20, 80%) than that in the control group (6 of 20, 30%) (P<0.01). Moreover, mice in the I/R group had significantly more tumor nodules compared to those in the control group (median, 9.9 vs. 2.7 nodules) (P<0.01). In the I/R+Ab group, only 2 of 5 (40%) mice developed liver metastases. RT-PCR and southern blotting of the liver extracts showed that the expression of IL-1 and E-selectin mRNA after hepatic ischemia-reperfusion was significantly higher than the basal levels. Hepatic ischemia-reperfusion increases liver metastases and E-selectin expression in pancreatic cancer. These results suggest that E-selectin produced due to hepatic ischemia-reperfusion is involved in liver metastasis. |
| 内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
Embargo Period 6 months |
| 権利 |
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権利情報 |
Copyright © Spandidos Publications |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
ME-PR-ISEKI-S-791.pdf (360.2 kB)
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