| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-05-07 |
| タイトル |
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|
タイトル |
Characterization of skin blister fluids from children with Epstein-Barr virus-associated lymphoproliferative disease |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
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|
ID登録 |
10.24517/00050510 |
|
ID登録タイプ |
JaLC |
| 著者 |
Wada, Taizo
Toma, Tomoko
Miyazawa, Hanae
Koizumi, Eiko
Shirahashi, Tetsujiro
Matsuda, Yusuke
Yachie, Akihiro
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| 著者別表示 |
和田, 泰三
東馬, 智子
白橋, 徹志郎
谷内江, 昭宏
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| 提供者所属 |
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内容記述タイプ |
Other |
|
内容記述 |
金沢大学附属病院小児科 |
| 書誌情報 |
Journal of Dermatology
巻 45,
号 4,
p. 444-449,
発行日 2018-04-02
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0385-2407 |
| NCID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00696658 |
| DOI |
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|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
10.1111/1346-8138.14226 |
| 出版者 |
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出版者 |
日本皮膚科学会 = Japanese Dermatological Association / Blackwell Publishing Ltd |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Epstein-Barr virus (EBV)-associated T- or natural killer (NK)-cell lymphoproliferative disease (LPD) is a heterogeneous group of disorders characterized by chronic proliferation of EBV-infected lymphocytes. Patients may present with severe skin manifestations, including hypersensitivity to mosquito bites (HMB) and hydroa vacciniforme (HV)-like eruption, which are characterized by blister formation and necrotic ulceration. Skin biopsy specimens show inflammatory reactions comprising EBV-infected lymphocytes. However, blister fluids have not been fully assessed in patients with this disease. Blister fluids were collected from three patients with EBV-associated LPD: two with HMB and one with HV. Immunophenotyping of blister lymphocytes and measurement of tumor necrosis factor (TNF)-α in blister fluids were performed. The patients with HMB and HV exhibited markedly increased percentages of NK and γδ T cells, respectively, in both peripheral blood and blister fluids. These NK and γδ T cells strongly expressed the activation marker human leukocyte antigen-DR and were considered to be cellular targets of EBV infections. TNF-α was highly elevated in all blister fluids. Severe local skin reactions of EBV-associated LPD may be associated with infiltrating EBV-infected lymphocytes and a high TNF-α concentration in blister fluids. © 2018 Japanese Dermatological Association. |
| 内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
Embargo Period 12 months |
| 権利 |
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|
権利情報 |
Copyright © 2018 Japanese Dermatological Association. |
| 著者版フラグ |
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出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連URI |
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識別子タイプ |
URI |
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関連識別子 |
https://www.dermatol.or.jp/modules/publication/index.php?content_id=3 |
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|
関連名称 |
https://www.dermatol.or.jp/modules/publication/index.php?content_id=3 |
HO-PR-WADA-T-444.pdf (179.2 kB)
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