| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-05-10 |
| タイトル |
|
|
タイトル |
Relationships between alanine aminotransferase (ALT), visceral adipose tissue (AT) and metabolic risk factors in a middle-aged Japanese population |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.24517/00050638 |
|
ID登録タイプ |
JaLC |
| 著者 |
Oka, Rie
Yamada, Takayoshi
Nakanishi, Chiaki
Konno, Tetsuo
Kawashiri, Masa-aki
Hayashi, Kenshi
Nohara, Atsushi
Inazu, Akihiro
Yamagishi, Masakazu
|
| 著者別表示 |
大家, 理恵
八木, 邦公
今野, 哲雄
川尻, 剛照
林, 研至
野原, 淳
稲津, 明広
山岸, 正和
|
| 提供者所属 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
金沢大学医薬保健研究域医学系 |
| 書誌情報 |
Journal of Atherosclerosis and Thrombosis
巻 21,
号 6,
p. 582-592,
発行日 2014
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1340-3478 |
| NCID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11018976 |
| 出版者 |
|
|
出版者 |
Japan Atherosclerosis Society = 日本動脈硬化学会 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Aim: The commonly observed relationship between increased visceral adiposity and metabolic abnormalities may be partly mediated by a concomitant increase in liver fat content. We evaluated the independent association between the level of alanine aminotransferase (ALT) as a surrogate marker of the liver fat content and the incidence of metabolic abnormalities after adjusting for the amount of visceral adipose tissue (AT). Methods: The subjects included 1,118 Japanese individuals (44% women) who underwent computed tomography to assess the amount of visceral AT on medical checkups. Cross-sectional associations between the serum ALT, visceral AT and metabolic risk factors were examined. Results: The ALT level and visceral AT were found to show a significant correlation (r =0.41 in men and r =0.36 in women, p<0.001). In a multivariable linear regression analysis, the ALT level and visceral AT were found to be independently associated with blood pressure in men and triglycerides and 2-hour post-challenge glucose in both genders (p<0.01), whereas only visceral AT was found to be associated with HDL-cholesterol (p<0.01). When the participants were classified into four subgroups based on the 75th percentiles of ALT and visceral AT, the low-ALT/high-visceral AT group, but not the high-ALT/low-visceral AT group, had a significantly higher odds ratio for low HDL-cholesterol among both genders (p<0.05) and for hypertriglyceridemia in men only (p<0.05). Meanwhile, the high-ALT/low-visceral AT group, but not the low-ALT/high-visceral AT group, had a significantly higher odds ratio for IGT among women (p<0.05). Conclusions: Although the ALT level and visceral AT were found to be independently associated with most metabolic risk factors, visceral AT had a dominant association with dyslipidemia in both genders, while the ALT level appeared to have a closer association with IGT in women. |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
出版者照会後に全文公開 |
| 権利 |
|
|
権利情報 |
Copyright © Japan Atherosclerosis Society 日本動脈硬化学会 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連URI |
|
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
https://www.jstage.jst.go.jp/browse/jat/-char/en |
|
|
関連名称 |
https://www.jstage.jst.go.jp/browse/jat/-char/en |
| 関連URI |
|
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
http://www.j-athero.org/ |
|
|
関連名称 |
http://www.j-athero.org/ |
ME-PR-YAMAGISHI-M-582.pdf (1.5 MB)
.png)
