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Post-prandial Remnant Lipoprotein Metabolism in Sitosterolemia
https://doi.org/10.24517/00053007
https://doi.org/10.24517/0005300746b66b2c-44a6-4d7d-a2fe-9241cf875ce9
名前 / ファイル | ライセンス | アクション |
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ME-PR-TADA-H-1188.pdf (790.5 kB)
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Item type | 学術雑誌論文 / Journal Article_04(1) | |||||
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公開日 | 2019-01-10 | |||||
タイトル | ||||||
タイトル | Post-prandial Remnant Lipoprotein Metabolism in Sitosterolemia | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00053007 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Tada, Hayato
× Tada, Hayato× Nomura, Akihiro× Nohara, Atsushi× Inazu, Akihiro× Mabuchi, Hiroshi× YAMAGISHI, Masakazu× Kawashiri, Masa-aki |
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著者別表示 |
多田, 隼人
× 多田, 隼人× 野村, 章洋× 野原, 淳× 稲津, 明広× 馬淵, 宏× 山岸, 正和× 川尻, 剛照 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学附属病院循環器内科 | |||||
書誌情報 |
Journal of Atherosclerosis and Thrombosis 巻 25, 号 12, p. 1188-1195, 発行日 2018 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1340-3478 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11018976 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.5551/jat.44768 | |||||
出版者 | ||||||
出版者 | 日本動脈硬化学会 = Japan Atherosclerosis Society | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Aim: We aimed to clarify post-prandial accumulation of remnant-like particles (RLP) in patients with sitosterolemia. \nMethods: Oral fat tolerance test cream (Jomo Shokuhin, Takasaki, Japan) 50 g was given per body surface area (m2); blood sampling was performed at 2 h intervals up to 6 h. Plasma lipoprotein fractions and RLP fractions were determined in four sitosterolemic subjects with double mutations in ATP-binding cassette (ABC) sub-family G member 5 or member 8 (ABCG5 or ABCG8) gene (mean age=18 yr, median low-density lipoprotein cholesterol [LDL-C]=154 mg/dL), six heterozygous carriers (mean age=31 yr, median LDL-C=105 mg/dL), and five subjects with heterozygous familial hypercholesterolemia (FH, mean age=32 yr, median LDL-C=221 mg/dL). The incremental area under curve (iAUC) of lipids, including LDL-C, apolipoprotein B-48 (apoB48), RLP cholesterol (RLP-C), and RLP triglyceride (RLP-TG) were evaluated. \nResults: After oral fat load, there was no significant difference of the iAUC of LDL-C between sitosterolemia and heterozygous FH, whereas the iAUC of apoB48 was significantly larger in the sitosterolemic subjects compared with that of heterozygous FH (2.9 µg/mL×h vs. 1.3 µg/mL×h, p<0.05). Under these conditions, the iAUCs of RLP-C and RLP-TG levels were significantly larger in the sitosterolemic subject compared with those of heterozygous FH (9.5 mg/dL×h vs. 5.7 mg/dL×h, p<0.05; 149 mg/dL×h vs. 40 mg/dL×h, p<0.05, respectively), whereas those of heterozygous carriers were comparable with those with heterozygous FH. \nConclusions: Post-prandial lipoprotein metabolism in sitosterolemia appeared to be impaired, leading to their elevation in serum sterol levels. (UMIN Clinical Trials Registry number, UMIN000020330) |
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内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | This article distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License. | |||||
権利 | ||||||
権利情報 | Copyright © 日本動脈硬化学会 Japan Atherosclerosis Society | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.jstage.jst.go.jp/browse/jat/-char/ja | |||||
関連名称 | https://www.jstage.jst.go.jp/browse/jat/-char/ja | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.j-athero.org/ | |||||
関連名称 | http://www.j-athero.org/ |