| アイテムタイプ |
学術雑誌論文 / Journal Article_04(1) |
| 公開日 |
2019-01-10 |
| タイトル |
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タイトル |
Post-prandial Remnant Lipoprotein Metabolism in Sitosterolemia |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| ID登録 |
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ID登録 |
10.24517/00053007 |
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ID登録タイプ |
JaLC |
| 著者 |
Tada, Hayato
Nomura, Akihiro
Nohara, Atsushi
Inazu, Akihiro
Mabuchi, Hiroshi
YAMAGISHI, Masakazu
Kawashiri, Masa-aki
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| 著者別表示 |
多田, 隼人
野村, 章洋
野原, 淳
稲津, 明広
馬淵, 宏
山岸, 正和
川尻, 剛照
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| 提供者所属 |
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内容記述タイプ |
Other |
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内容記述 |
金沢大学附属病院循環器内科 |
| 書誌情報 |
Journal of Atherosclerosis and Thrombosis
巻 25,
号 12,
p. 1188-1195,
発行日 2018
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1340-3478 |
| NCID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA11018976 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.5551/jat.44768 |
| 出版者 |
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出版者 |
日本動脈硬化学会 = Japan Atherosclerosis Society |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Aim: We aimed to clarify post-prandial accumulation of remnant-like particles (RLP) in patients with sitosterolemia.
\nMethods: Oral fat tolerance test cream (Jomo Shokuhin, Takasaki, Japan) 50 g was given per body surface area (m2); blood sampling was performed at 2 h intervals up to 6 h. Plasma lipoprotein fractions and RLP fractions were determined in four sitosterolemic subjects with double mutations in ATP-binding cassette (ABC) sub-family G member 5 or member 8 (ABCG5 or ABCG8) gene (mean age=18 yr, median low-density lipoprotein cholesterol [LDL-C]=154 mg/dL), six heterozygous carriers (mean age=31 yr, median LDL-C=105 mg/dL), and five subjects with heterozygous familial hypercholesterolemia (FH, mean age=32 yr, median LDL-C=221 mg/dL). The incremental area under curve (iAUC) of lipids, including LDL-C, apolipoprotein B-48 (apoB48), RLP cholesterol (RLP-C), and RLP triglyceride (RLP-TG) were evaluated.
\nResults: After oral fat load, there was no significant difference of the iAUC of LDL-C between sitosterolemia and heterozygous FH, whereas the iAUC of apoB48 was significantly larger in the sitosterolemic subjects compared with that of heterozygous FH (2.9 µg/mL×h vs. 1.3 µg/mL×h, p＜0.05). Under these conditions, the iAUCs of RLP-C and RLP-TG levels were significantly larger in the sitosterolemic subject compared with those of heterozygous FH (9.5 mg/dL×h vs. 5.7 mg/dL×h, p＜0.05; 149 mg/dL×h vs. 40 mg/dL×h, p＜0.05, respectively), whereas those of heterozygous carriers were comparable with those with heterozygous FH.
\nConclusions: Post-prandial lipoprotein metabolism in sitosterolemia appeared to be impaired, leading to their elevation in serum sterol levels. (UMIN Clinical Trials Registry number, UMIN000020330) |
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内容記述タイプ |
Other |
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内容記述 |
This article distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License. |
| 権利 |
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権利情報 |
Copyright © 日本動脈硬化学会 Japan Atherosclerosis Society |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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識別子タイプ |
URI |
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関連識別子 |
https://www.jstage.jst.go.jp/browse/jat/-char/ja |
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関連名称 |
https://www.jstage.jst.go.jp/browse/jat/-char/ja |
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識別子タイプ |
URI |
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関連識別子 |
http://www.j-athero.org/ |
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関連名称 |
http://www.j-athero.org/ |
ME-PR-TADA-H-1188.pdf (790.5 kB)
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