{"_buckets": {"deposit": "e1c77d7b-647f-4898-9b32-a100eda84df7"}, "_deposit": {"created_by": 18, "id": "48108", "owners": [18], "pid": {"revision_id": 0, "type": "depid", "value": "48108"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00048108", "sets": ["2815"]}, "author_link": ["2843", "85743"], "item_9_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-06-18", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "6p.", "bibliographicVolumeNumber": "2017-04-01 - 2019-03-31", "bibliographic_titles": [{"bibliographic_title": "平成30(2018)年度 科学研究費補助金 若手研究(B) 研究成果報告書"}, {"bibliographic_title": "2018 Fiscal Year Final Research Report", "bibliographic_titleLang": "en"}]}]}, "item_9_creator_33": {"attribute_name": "著者別表示", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Domoto, Takahiro"}], "nameIdentifiers": [{"nameIdentifier": "85743", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80635540", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=80635540"}]}]}, "item_9_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "多くのがん細胞に共通したエネルギー代謝特性である解糖系の亢進（Warburg 効果）とオートファジーに焦点を当てて、GSK3βのがん促進作用のメカニズムを検討した。大腸がん細胞ではGSK3βの活性化により、解糖系が亢進すること、及びオートファジー関連転写因子群の発現誘導によってオートファジー活性を亢進していることを見出した。GSK3β阻害剤の併用はオートファジー阻害剤による細胞増殖抑制効果を顕著に増強したことから、がん特有のエネルギー代謝を標的とした治療にGSK3βは格好の候補分子であることが示唆された。 ", "subitem_description_type": "Abstract"}, {"subitem_description": "We investigated the tumor-promoting mechanisms induced by GSK3β on energy metabolism including Warburg effect and autophagy. Aberrant GSK3β enhanced glycolysis, and led autophagic activation by induction of expression of autophagy-related transcription factors in colon cancer cells. Combined treatment with specific GSK3β inhibitor (AR-A014418) and autophagy inhibitor (hydroxychloroquine) synergistically suppressed proliferation of cancer cells. These results suggest that GSK3β is attractive candidate for cancer energy metabolism targeted therapy.", "subitem_description_type": "Abstract"}]}, "item_9_description_22": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "研究課題/領域番号:17K15022, 研究期間(年度):2017-04-01 - 2019-03-31", "subitem_description_type": "Other"}, {"subitem_description": "出典：研究課題「GSK3βが制御するがん特異的エネルギー獲得機構の解明とがん治療への応用」課題番号17K15022\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K15022/17K15022seika/）を加工して作成", "subitem_description_type": "Other"}]}, "item_9_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.24517/00054430", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_17": {"attribute_name": "公開者", "attribute_value_mlt": [{"subitem_publisher": "金沢大学がん進展制御研究所"}]}, "item_9_relation_28": {"attribute_name": "関連URI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "https://kaken.nii.ac.jp/search/?qm=80635540"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://kaken.nii.ac.jp/search/?qm=80635540", "subitem_relation_type_select": "URI"}}, {"subitem_relation_name": [{"subitem_relation_name_text": "https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K15022/"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K15022/", "subitem_relation_type_select": "URI"}}, {"subitem_relation_name": [{"subitem_relation_name_text": "https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K15022/17K15022seika/"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K15022/17K15022seika/", "subitem_relation_type_select": "URI"}}]}, "item_9_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "堂本, 貴寛"}], "nameIdentifiers": [{"nameIdentifier": "2843", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80635540", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=80635540"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-04-23"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "CA-PR-DOMOTO-T-kaken 2019-6p.pdf", "filesize": [{"value": "302.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 302000.0, "url": {"label": "CA-PR-DOMOTO-T-kaken 2019-6p.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/48108/files/CA-PR-DOMOTO-T-kaken 2019-6p.pdf"}, "version_id": "d1eb987b-0d6c-4e03-9019-025a77c3a417"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "分子標的治療", "subitem_subject_scheme": "Other"}, {"subitem_subject": "がん代謝", "subitem_subject_scheme": "Other"}, {"subitem_subject": "GSK3β", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "research report", "resourceuri": "http://purl.org/coar/resource_type/c_18ws"}]}, "item_title": "GSK3βが制御するがん特異的エネルギー獲得機構の解明とがん治療への応用", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "GSK3βが制御するがん特異的エネルギー獲得機構の解明とがん治療への応用"}, {"subitem_title": "Exploring biological basis of aberrant cancer energy metabolism induced by GSK3beta toward application to cancer treatment", "subitem_title_language": "en"}]}, "item_type_id": "9", "owner": "18", "path": ["2815"], "permalink_uri": "https://doi.org/10.24517/00054430", "pubdate": {"attribute_name": "公開日", "attribute_value": "2020-04-23"}, "publish_date": "2020-04-23", "publish_status": "0", "recid": "48108", "relation": {}, "relation_version_is_last": true, "title": ["GSK3βが制御するがん特異的エネルギー獲得機構の解明とがん治療への応用"], "weko_shared_id": -1}