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血管内皮細胞が肝発がん・再発に関わるメカニズムの解明
https://doi.org/10.24517/00058792
https://doi.org/10.24517/00058792d6761f8c-0777-4fbb-9543-8c51ee39d17a
名前 / ファイル | ライセンス | アクション |
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HO-PR-NISHIKAWA-M-kaken 2020-4p.pdf (244.7 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2021-05-13 | |||||
タイトル | ||||||
タイトル | 血管内皮細胞が肝発がん・再発に関わるメカニズムの解明 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Elucidation of the mechanism by which vascular endothelial cells are involved in liver carcinogenesis/recurrence | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00058792 | |||||
ID登録タイプ | JaLC | |||||
著者別表示 |
Nishikawa, Masashi
× Nishikawa, Masashi |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 独立行政法人国立病院機構 / 金沢大学附属病院 | |||||
書誌情報 |
令和1(2019)年度 科学研究費補助金 若手研究 研究成果報告書 en : 2019 Fiscal Year Final Research Report 巻 2018-04-01 – 2020-03-31, p. 4p., 発行日 2020-07-15 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | C型肝炎ウイルス排除達成(SVR)群とSVR後肝癌群の網羅的メチル化解析、および発現量解析にて今回TMEMを同定した。TMEMは新規かつ機能未知の遺伝子である。TMEMは腫瘍浸潤血管内皮細胞に発現が見られ、TMEM高発現群で有意に肝癌無再発期間が短期であった。TMEM過剰発現血管内皮細胞は、腫瘍形成を有意に亢進することが確認できた。TMEMは、ERストレス経路を介して腫瘍形成を亢進することが示された。TMEMは、肝発がん及び肝細胞癌の治療標的になり得ることが示唆された。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We identified TMEM this time by comprehensive methylation analysis of the group achieving sustained viral response (SVR) and HCC group after achieving SVR, and expression level analysis. TMEM is a novel gene of unknown function. TMEM was found to be expressed in tumor-infiltrating vascular endothelial cells, and the recurrence-free period of liver cancer was significantly short in the high TMEM-expressing group. It was confirmed that TMEM-overexpressing vascular endothelial cells significantly promote tumor formation. TMEM has been shown to enhance tumorigenesis via the ER stress pathway. It was suggested that TMEM could be a therapeutic target for liver carcinogenesis and hepatocellular carcinoma. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:18K15777, 研究期間(年度):2018-04-01 – 2020-03-31 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:「血管内皮細胞が肝発がん・再発に関わるメカニズムの解明」研究成果報告書 課題番号18K15777 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18K15777/18K15777seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/search/?kw=90794511 | |||||
関連名称 | https://kaken.nii.ac.jp/ja/search/?kw=90794511 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-18K15777/ | |||||
関連名称 | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-18K15777/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18K15777/18K15777seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18K15777/18K15777seika/ |