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Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis
https://doi.org/10.24517/00062985
https://doi.org/10.24517/000629857ee57b43-78b4-4308-8131-ba409272a12c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-NAITO-H-1072.pdf (2.9 MB)
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2021-07-05 | |||||
| タイトル | ||||||
| タイトル | Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| ID登録 | ||||||
| ID登録 | 10.24517/00062985 | |||||
| ID登録タイプ | JaLC | |||||
| 著者 |
Kidoya, Hiroyasu
× Kidoya, Hiroyasu× Muramatsu, Fumitaka× Shimamura, Teppei× Jia, Weizhen× Satoh, Takashi× Hayashida, Yumiko× Naito, Hisamichi× Kunisaki, Yuya× Arai, Fumio× Seki, Masahide× Suzuki, Yutaka× Osawa , Tsuyoshi× Akira , Shizuo× Takakura, Nobuyuki |
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| 著者別名 |
内藤, 尚道
× 内藤, 尚道× 高倉, 伸幸 |
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| 提供者所属 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 金沢大学医薬保健研究域医学系 | |||||
| 書誌情報 |
Nature Communications 巻 10, 号 1, p. 1072, 発行日 2019-03-06 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2041-1723 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA12645905 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/s41467-019-09028-w | |||||
| 出版者 | ||||||
| 出版者 | Nature Research / Nature Publishing Group | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The balance between self-renewal and differentiation of hematopoietic stem and progenitor cells (HSPCs) maintains hematopoietic homeostasis, failure of which can lead to hematopoietic disorder. HSPC fate is controlled by signals from the bone marrow niche resulting in alteration of the stem cell transcription network. Regnase-1, a member of the CCCH zinc finger protein family possessing RNAse activity, mediates post-transcriptional regulatory activity through degradation of target mRNAs. The precise function of Regnase-1 has been explored in inflammation-related cytokine expression but its function in hematopoiesis has not been elucidated. Here, we show that Regnase-1 regulates self-renewal of HSPCs through modulating the stability of Gata2 and Tal1 mRNA. In addition, we found that dysfunction of Regnase-1 leads to the rapid onset of abnormal hematopoiesis. Thus, our data reveal that Regnase-1-mediated post-transcriptional regulation is required for HSPC maintenance and suggest that it represents a leukemia tumor suppressor. © 2019, The Author(s). | |||||
| 権利 | ||||||
| 権利情報 | copyright © Nature Research | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.nature.com/ncomms/index.html | |||||
| 関連名称 | http://www.nature.com/ncomms/index.html | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.nature.com/articles/s41467-019-09028-w | |||||
| 関連名称 | https://www.nature.com/articles/s41467-019-09028-w | |||||
