| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2022-03-11 |
| タイトル |
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タイトル |
Visualization of dynamic expression of myocardial Sigma-1 receptor after myocardial Ischemia and reperfusion using radioiodine-labeled 2-[4-(2-iodophenyl)piperidino]cyclopentanol (OI5V) imaging |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| ID登録 |
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|
ID登録 |
10.24517/00065230 |
|
ID登録タイプ |
JaLC |
| 著者 |
Wakabayashi, Hiroshi
Taki, Junichi
Mori, Hirofumi
HIROMASA, Tomo
Akatani, Norihito
Inaki, Anri
Kozaka, Takashi
Shiba, Kazuhiro
Ogawa, Kazuma
Kinuya, Seigo
|
| 著者別表示 |
若林, 大志
瀧, 淳一
廣正, 智
稲木, 杏吏
小阪, 孝史
柴, 和弘
小川, 数馬
絹谷, 清剛
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| 提供者所属 |
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内容記述タイプ |
Other |
|
内容記述 |
金沢大学疾患モデル総合研究センター |
| 書誌情報 |
Circulation Journal
巻 85,
号 11,
p. 2102-2108,
発行日 2021
|
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1346-9843 |
| NCID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11591968 |
| DOI |
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|
関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1253/circj.CJ-21-0320 |
| 出版者 |
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出版者 |
Japanese Circulation Society |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Background: This study chronologically evaluated the expression of the intensity and distribution of the sigma-1 receptor (σ1R) demonstrated by radiolabeled 2-[4-(2-iodophenyl)piperidino]cyclopentanol (OI5V) in a rat model of myocardial ischemia and reperfusion. Methods and Results: The left coronary artery was occluded for 30 min, followed by reperfusion. Dual-tracer autoradiography with 125I-OI5V and 99 mTc-MIBI was performed to assess the spatiotemporal changes in 125I-OI5V uptake (n=5-6). Significant and peaked 125I-OI5V uptake in the ischemic area was observed at 3 days after reperfusion, and the 125I-OI5V uptake ratio of ischemic area to normally perfused left ventricular area decreased gradually from 3 to 28 days (mean value ± SD; 0.90±0.12 at 1 day, 1.89±0.19 at 3 days, 1.52±0.17 at 7 days, 1.34±0.13 at 14 days, and 1.16±0.14 at 28 days, respectively). Triple-tracer autoradiography with 125I-OI5V, 99 mTc-MIBI, and 201TlCl was performed to evaluate 125I-OI5V uptake in the ischemic area in relation to the residual perfusion at 7 days (n=4). The 125I-OI5V uptake ratio of the non-salvaged area was higher compared to that of the salvaged area in the ischemic area. 123I-OI5V and 99 mTc-MIBI SPECT/CT was performed 3 days after reperfusion (n=3), and the in vivo images showed clear uptake of 123I-OI5V in the perfusion defect area. Conclusions: The present study confirmed the spatiotemporal expression pattern of σ1R expression. Non-invasive σ1R imaging with 123I or 125I-OI5V was feasible to monitor the expression of σ1R after myocardial ischemia and reperfusion. © 2021 Japanese Circulation Society. All rights reserved. |
| 権利 |
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|
権利情報 |
Copyright © Japanese Circulation Society 日本循環器学会 |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連URI |
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識別子タイプ |
URI |
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関連識別子 |
http://www.plosone.org/ |
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関連名称 |
http://www.plosone.org/ |
| 関連URI |
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識別子タイプ |
URI |
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関連識別子 |
https://www.jstage.jst.go.jp/browse/circj/-char/ja/ |
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関連名称 |
https://www.jstage.jst.go.jp/browse/circj/-char/ja/ |
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