| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-10-03 |
| タイトル |
|
|
タイトル |
Cell fate of müller cells during photoreceptor regeneration in an N-methyl-N-nitrosourea- induced retinal degeneration model of zebrafish |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.24517/00014262 |
|
ID登録タイプ |
JaLC |
| 著者 |
Ogai, Kazuhiro
Hisano, Suguru
Sugitani, Kayo
Koriyama, Yoshiki
Kato, Satoru
|
| 著者別表示 |
大貝, 和裕
杉谷, 加代
郡山, 恵樹
加藤, 聖
|
| 書誌情報 |
Advances in Experimental Medicine and Biology
巻 854,
p. 685-692,
発行日 2016-10-01
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0065-2598 |
| NCID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00512642 |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1007/978-3-319-17121-0_91 |
| 出版者 |
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出版者 |
Springer |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Zebrafish can regenerate several organs such as the tail fin, heart, central nervous system, and photoreceptors. Very recently, a study has demonstrated the photoreceptor regeneration in the alkylating agent N-methyl-N-nitrosourea (MNU)- induced retinal degeneration (RD) zebrafish model, in which whole photoreceptors are lost within a week after MNU treatment and then regenerated within a month. The research has also shown massive proliferation of Müller cells within a week. To address the question of whether proliferating Müller cells are the source of regenerating photoreceptors, which remains unknown in the MNU-induced zebrafish RD model, we employed a BrdU pulse-chase technique to label the proliferating cells within a week after MNU treatment. As a result of the BrdU pulse-chase technique, a number of BrdU+ cells were observed in the outer nuclear layer as well as the inner nuclear layer. This implies that regenerating photoreceptors are derived from proliferating Müller cells in the zebrafish MNU-induced RD model. © Springer International Publishing Switzerland 2016. |
| 内容記述 |
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|
内容記述タイプ |
Other |
|
内容記述 |
[Book Chapter] |
| 権利 |
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|
権利情報 |
The final publication is available at www.springerlink.com/article/chapter/10.1007%2F978-3-319-17121-0_91 |
| 著者版フラグ |
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|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
ME-PR-OOGAI-K-685.pdf (363.5 kB)
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