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Cell fate of müller cells during photoreceptor regeneration in an N-methyl-N-nitrosourea- induced retinal degeneration model of zebrafish
https://doi.org/10.24517/00014262
https://doi.org/10.24517/00014262e78c7c65-d38d-49a8-83db-5aba0ddabd66
| 名前 / ファイル | ライセンス | アクション |
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ME-PR-OOGAI-K-685.pdf (363.5 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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| 公開日 | 2017-10-03 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Cell fate of müller cells during photoreceptor regeneration in an N-methyl-N-nitrosourea- induced retinal degeneration model of zebrafish | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | journal article | |||||||||||||
| ID登録 | ||||||||||||||
| ID登録 | 10.24517/00014262 | |||||||||||||
| ID登録タイプ | JaLC | |||||||||||||
| 著者 |
Ogai, Kazuhiro
× Ogai, Kazuhiro× Hisano, Suguru× Sugitani, Kayo× Koriyama, Yoshiki× Kato, Satoru |
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| 著者別表示 |
大貝, 和裕
× 大貝, 和裕
× 杉谷, 加代
× 郡山, 恵樹
× 加藤, 聖
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| 書誌情報 |
Advances in Experimental Medicine and Biology 巻 854, p. 685-692, 発行日 2016-10-01 |
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| ISSN | ||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||
| 収録物識別子 | 0065-2598 | |||||||||||||
| NCID | ||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||
| 収録物識別子 | AA00512642 | |||||||||||||
| DOI | ||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | 10.1007/978-3-319-17121-0_91 | |||||||||||||
| 出版者 | ||||||||||||||
| 出版者 | Springer | |||||||||||||
| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Zebrafish can regenerate several organs such as the tail fin, heart, central nervous system, and photoreceptors. Very recently, a study has demonstrated the photoreceptor regeneration in the alkylating agent N-methyl-N-nitrosourea (MNU)- induced retinal degeneration (RD) zebrafish model, in which whole photoreceptors are lost within a week after MNU treatment and then regenerated within a month. The research has also shown massive proliferation of Müller cells within a week. To address the question of whether proliferating Müller cells are the source of regenerating photoreceptors, which remains unknown in the MNU-induced zebrafish RD model, we employed a BrdU pulse-chase technique to label the proliferating cells within a week after MNU treatment. As a result of the BrdU pulse-chase technique, a number of BrdU+ cells were observed in the outer nuclear layer as well as the inner nuclear layer. This implies that regenerating photoreceptors are derived from proliferating Müller cells in the zebrafish MNU-induced RD model. © Springer International Publishing Switzerland 2016. | |||||||||||||
| 内容記述 | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | [Book Chapter] | |||||||||||||
| 権利 | ||||||||||||||
| 権利情報 | The final publication is available at www.springerlink.com/article/chapter/10.1007%2F978-3-319-17121-0_91 | |||||||||||||
| 著者版フラグ | ||||||||||||||
| 出版タイプ | AM | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||
